One of her most recent roles was as the character Berthe in Broadway’s Pippin in 2014. Lucie also had a successful theater career with roles in shows like Annie Get Your Gun, Broadway’s They’re Playing Our Song, The Wizard of Oz in Concert: Dreams Come True and The Witches of Eastwick. She also had her own talk show from 1985 to 1986. Lucie went on to star in projects like Who Is the Black Dahlia Fantasy Island Murder, She Wrote Law & Order and Sons & Daughters, as well as her own CBS series, The Lucie Arnaz Show, which aired for one season on CBS in 1985. (Lucie played Kim Carter, the daughter of her mother’s character, Lucy.) She had walk-on roles on her mother’s I Love Lucy follow-up, The Lucy Show, which ran from 1962 to 1968, and made her acting debut in her mother’s next show, Here’s Lucy, which aired from 1968 to 1974. Like her parents, Lucie was also an actor. Lucie Arnaz-Lucille Ball and Desi Arnaz‘s first child and only daughter-was born on July 17, 1951, six months before the premiere of I Love Lucy. Lucie was born and raised in Los Angeles, California, with her younger brother, Desi Arnaz Jr., but moved to New York City for a few years as preteen and teenager. Arnaz, now and how much did they inherit after their mother death? Read on for what we know about what’s happened to Lucie and Desi Jr. So where are Lucille Ball’s kids, Lucie and Desi Jr. It is hard to maintain a working relationship, as well as a relationship with someone you love and is your partner in raising kids.” But I also think it is also an equal triumph to have a relationship that was the kind that they had. So much is made of their work and comedy, and it should be. But at the end of the day, the attempt was to tell a love story: Their long journey of falling in love, working, and staying in love with each other through thick and thin was echoed in their show.” Poehler continued, “And then to watch America’s most powerful couple - they created the idea of a power couple - split up after being on TV, as this example of how things will always be OK, it was interesting. “These two incredible outsiders worked hard to become powerful, influential figures at a time when women and immigrants were not running the system. “I knew about them as performers, not as people,” Poehler told Variety in 2021. The story of Ball and Arnaz’s relationship was told in Amy Poehler’s 2022 documentary, Lucy and Desi, which dove into who they were as people in addition to Hollywood stars. Their second child, a son named Desi Jr., was born in 1953 and became a part of the show’s storyline. The couple welcomed their first child, a daughter named Lucie, in 1951, less than a year after the premiere of I Love Lucy. After the success of the tour, CBS greenlit I Love Lucy, which went on to run for more than 100 episodes and be one of the most-watched shows in TV history. Unimpressed by the pilot episode, CBS turned down a show with Ball and Arnaz, which led them to hit the road as a vaudeville act in which Ball played a zany housewife who tried to get into her husband’s show. After the success of My Favorite Husband, Ball was asked by CBS to develop it for television, which she agreed if she could work with her real-life husband, Arnaz. In 1948, Ball was cast as Liz Cooper, a wacky wife in the CBS Radio comedy show, My Favorite Husband. ![]() Lucille Ball and Desi Arnaz-Lucie and Desi Jr.’s parents-met on the set of the stage show, Too Many Girls, in 1940. Arnaz, are now and what their mother left them after she died in 1989. If you loved Lucy her whole life, you may want to know where Lucille Ball’s kids, Lucie and Desi Jr.
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![]() Theme for the results screen at the end of battles. ![]() Also used for the Fire Dragon boss at the end of the Thabes Labyrinth Fifth Basement.īoss battle theme for Berkut in Acts 3 and Act 4.Īdapted from track 85 ("Battle 4 (Final Boss)") from Gaiden.Īdapted from track 82 ("Using Heal Staff") from Gaiden. Player phase battle theme used from Act 5 onward.Īdapted from track 80 ("Finale ~ Ally Attack") from Gaiden.Īdapted from track 64 ("Battle 2 (CP)") from Gaiden.Īdapted from track 62 ("Battle 3 (Mid-Boss)") from Gaiden.īoss battle theme for Jedah. Used until Act 5.Īdapted from track 70 ("Battle 1 (Player)") from Gaiden it is a slightly different arrangement of this track compared to "The Dauntless Blade". Player phase battle theme when Celica is leading the party. Used until Act 5.Īdapted from track 70 ("Battle 1 (Player)") from Gaiden. Player phase battle theme when Alm is leading the party. ![]() Map and battle theme used in the Altar of Duma battle in Act 5.Īdapted from track 92 ("Final Map BGM (Player)") from Gaiden. ![]() Map theme in the battle with Berkut in Act 5.Įvent theme in the opening of the Altar of Duma battle in Act 5, when Duma rises. Map and battle theme used in the entirety of the Attack on Rigel Castle in Act 4. Also used as the player phase map and battle theme in the Prologue.Įnemy phase map and battle theme in the Prologue. Preparations theme for the Altar of Duma battle in Act 5.Īlm's first player phase map theme, used in Act 1.Īdapted from track 81 ("Battle Map 1-1 (Alm 1)") from Gaiden it is a softer, quieter variant of "March to Deliverance".Īlm's second player phase map theme, used in his maps in Act 3.Īdapted from track 81 ("Battle Map 1-1 (Alm 1)") from Gaiden.Īlm's third player phase map theme, used in his maps in Acts 4 and 5, and in 6 when he is leading the party.Īdapted from track 83 ("Battle Map 1-2 (Alm 2)") from Gaiden, with the addition of bars from "With Pride in your Heart".Ĭelica's first player phase map theme, used in Act 2.Īdapted from track 84 ("Battle Map 2-1 (Celica 1)") from Gaiden it is a softer, quieter variant of "With Mila's Divine Protection".Ĭelica's second player phase map theme, used in her maps in Act 3.Īdapted from track 84 ("Battle Map 2-1 (Celica 1)") from Gaiden.Ĭelica's third player phase map theme, used in her maps in Act 4, and in 6 when she is leading the party.Īdapted from track 88 ("Battle Map 2-2 (Celica 2)") from Gaiden, with the addition of bars from "Undiscovered Horizons" and "A Song for Bygone Days".Īdapted from track 56 ("Battle Map BGM 1 (CP)") from Gaiden it is a softer, quieter variant of "The Air of Brutality".Įnemy phase map theme in Alm's Act 3 and 4 maps.Īdapted from track 56 ("Battle Map BGM 1 (CP)") from Gaiden.Īdapted from track 63 ("Battle Map BGM 2 (CP)") from Gaiden it is a softer, quieter variant of "Disquieting Steps".Įnemy phase map theme in Celica's Act 3 and 4 maps.Īdapted from track 63 ("Battle Map BGM 2 (CP)") from Gaiden.Īdapted from track 93 ("Final Map BGM (CP)") from Gaiden. Preparations theme when Celica is leading the party. Preparations theme when Alm is leading the party. Songs appearing in the Sound Test The sound test of Fire Emblem Echoes: Shadows of ValentiaĪdapted from track 80 ("World Map - Act 1") from Gaiden.Īdapted from track 95 ("World Map - Act 2") from Gaiden.Īdapted from track 76 ("World Map - Act 3") from Gaiden.Īdapted from track 78 ("World Map - Act 4") from Gaiden.Īdapted from track 67 ("World Map - Act 5") from Gaiden. 2 Songs not appearing in the Sound Test. ![]()
![]() While presenting his work, a pointillism piece that includes pictures of all the citizens in Pawnee, creating an image of the city hall, he refers to it as a "murinal" rather than a mural, opening him up to ridicule from the entire department. When one of the city hall murals is defaced, the Parks Department is tasked with creating a new mural in the episode " The Camel". It's also been revealed that Garry was once hit by a fire truck and had to have plastic surgery. When asked if he knew about this, Garry responded that he didn't know he was adopted. Mark Brendanawicz reveals Garry's adoptive mother, was arrested for marijuana. Dave Sanderson states Garry has had a few public urination violations. ![]() In the episode " Practice Date", while the Parks Department is attempting to dig up dirt on one another, several things come out about Garry. Garry's personality is not very developed at this point in the show, and his role mostly consists of being the co-worker who is constantly mocked by the other employees. Outside of work, mainly with his family, he is shown to be often charismatic, confident and well liked. He is also a skilled pianist, an amateur inventor, a good chef and a talented painter.ĭue to his reputation as a sad excuse for a human, Garry is often dismissed even if he is clearly in the right and what he has created is breathtaking. He once created a mural of an alcove of Pawnee City Hall, which was actually composed of small pictures of Pawnee citizens. He seems to have a normal family life and a strong artistic side. While he is the butt of endless mockery, he is shown to have one of the happiest and most fulfilled lives of any character. ![]() Garry was often mistreated due to his embarrassing history, which is a collection of awkward incidents resulting from his apparent clumsiness and ineptitude. His wife Gayle is a beautiful blonde woman, and their daughters are similarly attractive. Garry was a married father of three girls, who worked for the Department of Parks and Recreation. ![]() If you find you have so many recipes it might be time for a purge, or to keep things in separate binders These become the your dividers and tab labels. How do you search for recipes? Do you search by: I'd like to receive the free email course.ĭon't forget to check your inbox to confirm! We'll never send you spam. If you fill this in, you will be marked as a spammer. You want to find the ‘clearview’ ones that will allow you to insert your own printed cover and spine like this one (from Amazon): For something custom, try Company Folders.If you decide to use the Arc planner system, they also have page protectors (you will need to purchase the ones especially made to suit the binder rings) Where to find binders: You could also laminate your recipe pages. It allows you to reposition and move pages aroundĪre you messy in the kitchen? I am :p I use plastic page protectors to protect my recipe pages. – The Arc planner – this is what I use for my daily/weekly/monthly planner. – In a binder (I recommend letter size binders rather than half size (8.5 x 5.5″) so you can print recipes at a size big enough to read) How do you want to organize your recipes? I normally use this recipe page (see photo 4) which allows enough room to write.įor long recipes I recommend the recipe page and the photo + comments + storage instructions page from this recipe binderĪnd if you love monograms, you’ll love this recipe page or this oneĢ. If you make shorter recipes or don’t mind a small font size, I recommend recipe cards (either one page or two page). The photos (if there are any) are also typically quite small. The font is also small on those print outs and the font styles sometimes hard to read when printing directly from a website. When recipes are written in long sentences it’s easy to lose your place so you have to re-read all the instructions to find out what that next ingredient was, then then you’re also likely to forget to put in ingredients (as I have done before and it’s ruined the recipe). I like recipes to have each step broken out in a clear and easy to read way, like this: So you may be wondering: if you like the recipe why not just keep the print out page that you wrote the notes on? The reason is that they write out the recipe instructions in long drawn out sentences (which I absolutely cannot stand). The reason I do this is because multiple times I’ve tried recipes that I didn’t like, so there’s no point going to the effort of typing out the recipe onto a nice recipe page if you’re never going to make it again. Sort the recipes into binders with tabs for various categories (there’s a list later in this post).Place the recipe page into a plastic sleeve (to protect from kitchen spills).If the recipe is good, then I re-type it into one of my recipe binder printables.Make the recipe and write any comments, notes, ingredient changes, tips, storage instructions, conversions of cups to grams and vise versa etc.Print the recipe straight off that website.Find a recipe I want to make (usually online via websites such as, , blogs etc.Want to organize your recipes but aren’t sure where to start? To organize my recipes I do the following: I’ve purchased printables from you – how should I set up my planner?.What is a Printable? What happens when I purchase a printable from you?.Why printables? Do you sell printed versions of your products?.Shop my favorite planner supplies on Amazon.200 Blog Post Title Prompts (For Any Type of Blog). ![]() 54 Mistakes Etsy Sellers Make (And How to Fix Them).200 Blog Post Title Prompts (Exclusive Download Content).1200 Blog Post Ideas (Exclusive Download Content).Free Graphic Design Video Tutorials Library.Digital planners and notebooks in Microsoft PowerPoint.Free Printables Library – Subscribers Login. ![]() Browse our free templates for nutrition designs you can easily customize and share. 93,000+ vectors, stock photos & psd files. Web download this nutrition introduction infographic template and make vivid nutrition infographic on your own! Web browse our collection of printable tip sheets and resources. ![]() Web create free nutrition flyers, posters, social media graphics and videos in minutes. Web 70+ instagram nutrition infographics templates for canva | nutrition instagram square posts | instagram template kit for. 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Web fortunately, food infographic templates and posters are easier to edit and download with easelly’s infographic. ![]() Nutrition Infographic Template - Web download this free vector about creative nutrition infographic, and discover more than 25 million professional graphic resources. ![]() If you have had an astrology report, you will know what are periods are auspicious for you. The details provided in the 'Almanac' can help you to time events in your life so that you initiate all new plans during auspicious periods, hence bringing fruitful results. You can use the above information to find out what their current alignments are and affects should be. If you have had an astrology reading, you will know how different planets affect your life and the roles they play. Astrologers relate this information to the position of the planets in a known horoscope (any person's horoscope) and take this account while making predictions about the present and future. This shows the current position of the planets and the zodiacs through which they are passing. The chart given in the 'Ephemeris' is the horoscope chart for today, cast at the time shown. Until mid-May, channels for recreation, play, entertainment, hobbies, and creativity open up. Its transit of your joy sector is a boon for romance, spirit, and pleasure. Match the dates on this page with the prevailing dates in Odesa, for your applicable predictions. Your lucky, optimistic ruler continues to harmonize with your sign until mid-May this year, dear Sagittarius.Although the above horoscope chart has been cast according to our location, the information on this page is updated according to Eastern Standard Time (EST/EDT, 01:49), or the New York, US time zone, so as to cover the widest section of visitors.If you are single, be prepared for discussions about your status at home, which you may not find agreeable. Today's temper may be irritable and a petty argument with your partner may cause annoyance. Today, take the opportunity to discover a new pastime and indulge yourself. In fulfilling the obligations towards your loved ones, you may have overlooked your own needs. However, divulging your deepest secrets or personal emotions to your significant other at this time is not recommended. The support of your family members shall validate your convictions and you shall feel blessed by their presence. It is possible that an old acquaintance may request financial assistance from you today, but it is essential to weigh the pros and cons, as extending help could adversely affect your financial situation. Your good fortune lies in having such people in your life and you should cherish them. The Gemini natives associated with any business will see. (You know how one thing leads to another – just like sex leads to close dancing.) The main thing is this will be a productive day for you because you have the energy to look for what you want to find.Under the guidance of the cosmos, you are destined to relish the jolly company of your witty kin, that shall surely elevate your spirits and alleviate the mundanity of everyday life. Dear Gemini, this year will be quite beneficial for you, as per the Gemini horoscope 2023 predictions. 19) You have lots of energy to research whatever interests you today, which might mean getting lost in a maze of Google entries. You want to enlighten someone about something because you need to get something off your chest, (which is not easy if you have to keep your shirt on.) Find someone who wants to listen to you.Ĭapricorn (Dec. 21) Today you need to express your ideas to others. ![]() But privately, you are also thinking about what you most value and how you can expand this in your world, as well. You want to make plans to make more money. 21) Today you are thinking about moneymaking ideas and ways to improve your business and commercial scene. You need to talk! This is a great day for those who are lecturing, talking, teaching, acting and even writing. 22) Today you are loquacious, garrulous, voluble, effusive and downright chatty! Yada, yada, yada. Discussions with family members or people you live with will be lively and productive. 22) This is a good day to tackle home repairs and do-it-yourself projects at home because you have lots of energy to make home improvements right now. You might play a joke on someone because you feel prankish. Even though you will work, what you really want to do is relax and use your mind for amusing diversions like reading, writing, playing games and schmoozing with others. 22) You feel playful and energetic today. “Build that bridge!” “Move that mountain!” You will also talk a lot and be busy delegating. Expect to take a hands-on approach to whatever you do. In fact, people are so energetic they might blow the hair back over your ears.Ĭancer (June 21-July 22) You have definite opinions about what you want to do at work today, which is why you will roll up your sleeves and get busy. Gemini (May 21-June 20) You will enjoy talking to friends and partners today because these discussions will be dynamic, lively and informative! You will learn something new and interesting. ![]() ![]() They are not intended to diagnose, treat, cure, or prevent any disease. ![]() Organic tea leaves are hand sewn around flowers, creating Leaves of Art that slowly blossom into a bouquet of breathtaking shapes and exquisite flavors. Flowering Tea is the most innovative art form in loose tea. The statements made or products sold through this site have not been evaluated by the Food and Drug Administration (FDA) or by EU Health Authorities. Experience the art of blossoming tea Tea leaves and fragrant flowers bloom into exquisite shapes when steeped. Consult with your physician before using this productģ. Do not use unproven, unbranded products, which can pose serious risks to your health.Ģ. California Proposition 65 WARNING : Some products on this website contains progesterone, a chemical known to the State of California to cause cancer. Set comes with a 16oz Glass tea infusion bottle with strainer. ![]() The Pleasure: After enjoying the first pot, a Flowering Tea may be re-steeped 2-3 more times.ġ. offers nationally branded products that are produced according to manufacturing standards set by regulators at everyday low prices. Organic Tea gift set includes contains 24 tea bags, 6 of each of the following flavors: Breakfast Blend (for Focus), Aged Earl Grey (for Balance), Jasmine Green (to Reflect), and Moroccan Mint (Refresh). Allow to steep 2-3 minutes, to desired strength. Behold the magic of the unfolding tea leaves. The Suspense: Bring water to a boil and pour over tea. The Beginning: Place one Flowering Tea in a durable glass teapot.Steeping Instructions for Flowering Teas: A simple luxury that heightens the tea experience and makes for a conversation piece, these Leaves of Art are a true tea lover's bliss. The stylish glass teapot included is ideal for observing the flowering tea petals. Tea by Mood gift box contains the following Numi Tea blends: Breakfast Blend (for Focus), Aged Earl Grey (for Balance), Emperor's Pu-erh (to Energize), Jasmine Green (to Reflect), Mate Lemon (to Invigorate), Rooibos Chai (to Inspire), Moroccan Mint (Refresh) and Chamomile Lemon (to Sleep). I feel so grateful.Packaged in an exotic hand-made dark mahogany bamboo case, this Flowering Tea Gift Set is filled with six bouquets of tea leaves that blossom into a myriad of flavors from sweet and subtle to rich and bold. Buy this fancy tea for the holidays, Thanksgiving, or Christmas. □ FYI, Flower tea has enough taste and fragrance, even if you brew it with 300ml hot water three times in a row □ One Flower tea stick can be brewed about 1 liter, and it's enough for 3~4 people to enjoy the tea time. □ Enjoy the rich taste and fragrance of flower tea with your eyes, nose, and mouth □ Flower tea has enough taste and fragrance. How to Drink Flower Tea Stick? □ Pour hot water into the teacup to heat and clean the cup □ Discard the water and put the flower tea stick in the cup □ Pour hot water over 95 degrees again (300ml) □ While the tea is brewing, block the top of the cup so that it is blocked from cold air. □Composition Mugwort x 2 Korean Mint x 1 Chrysanthemum x 1 Siberian Chrysanthemum x 1. I can use it multiple times when I pour it into one cup or decide to make 1 liter for each tea stick. KKOKDAM does not add any food additives and provides a natural flavor. I love sitting in my backyard on my hammock and furniture to have exciting conversations with friends and family. My experience of drinking tea has gone to the next level of wellness, well-being, and satisfaction with a tea that makes me feel unique, elegant, and classic. I pour hot water into the teacup and use the tea stick like a bag. The Flower Tea Stick is self-designed and created by KKOKDAM, a brand recognized in Korea for its originality and creativity. Review ⭐⭐⭐⭐⭐ (5 STARS) I am so delighted with this luxurious tea sticks collection gift box made in the shape of a flower with its stem this unique idea brings the experience of drinking tea to the next level. Brand □ Buy the □ Flower Teastick Gift Box □ ASSORTED FLOWER TEA STICK GIFT SET □ □□ All of KKOKDAM Flower Tea products are made in Korea.□□. From our award-winning Flowering Tea gift set to our new Wander with Purpose set that offers a peek into the lives of the people who grow your tea, our unique gifts will surprise and delight anyone on your gift-giving list. CLICK HERE ON MY BIO LINK □□□ TO BUY THIS FANCY TEA. Numi’s gift items are the perfect answer for all types of tea lovers. Consists of traditional and complex tea flavors including the favorites such as assam tea in Aged Earl Grey, Breakfast Blend, Chamomile Lemon. Get a 15% Discount code with my EXCLUSIVE CODE □□□ KKOKDAMYENIS□□□ #ad. NUMI TEA ORGANIC TEA GIFT SET 32 assorted tea bags of 16 unique flavors, 2 teabags each flavor in a new compostable plant-based tea wrapper. Likewise, I’d be fine with OS X slowing down a bit. Apple could tidy up the new features in iOS 8, and polish the rough bits, turning iOS 8 into a mature mobile operating system not a mere rung in the iOS ladder to the sky. It’s interesting to think about what a Snow Leopard moment for iOS could look like. I don’t think the market will let Apple slow down on iOS, however, The space is competitive, and Android is looking better and better each year. ![]() Pundits have said that for years, and that bulleted list a few paragraphs up is a little frightening in that regard. The problem is - of course - that Apple may be stretched too thin. While it’s possible that all of these things will make it into the Keynote, it’s a whole hell of a lot of stuff to talk about.Įverything on that list is exciting, and with Apple on the hook for annual releases, chances are iOS 9 and Mac OS X 10.11 are just around the corner. Here’s a list of potential talking points, in no particular order: With WWDC coming up, the annual topic of what Apple will highlight is back on my mind. The difference between iOS 8 and Snow Leopard is that former brought many user-facing features, while the latter only really had one: Exchange support. Swift, third-party keyboards, Extensions, TouchID APIs, better notifications and more showed up with iOS 8. Snow Leopard was heralded as a “love letter to Mac developers.” The phrase surfaced again last year, and was thrown around a lot after WWDC 2014, and for a long list of good reasons. Instead, we’re going to concentrate 100% on the things that affect you, the developers.” We’re not going to overextend ourselves adding a raft of new customer-facing, marketing-friendly features. The overall message from Apple to developers was something like this: “We’re adding a ton of new things to Mac OS X that will help you write better applications and make your existing code run faster, and we’re going to make sure that all this new stuff is rock-solid and as bug-free as possible. Now they were applauding zero new features for Snow Leopard? What explains this? Many of these same developers applauded the “150+ new features” in Tiger and the “300 new features” in Leopard at past WWDCs. There were even a few hoots and whistles. ![]() After the rapid-fire updates of 10.1, 10.2, and 10.3 followed by the riot of new features and APIs in 10.4 and 10.5, could Apple really get away with calling a “time out?” I imagine Bertrand was really sweating this announcement up on the stage at WWDC in front of a live audience of Mac developers. In his review of 10.6, John Siracusa wrote: QuickTime X and Safari 4 shipped with the OS, and things like Grand Central Dispatch, OpenCL and much more robust 64-bit support all shipped with Snow Leopard, as well, no to mention Exchange support, which was a big step forward for the Mac in enterprise environments.Īll that said, however, Snow Leopard lacked the laundry list of new features that OS X customers had grown use to. Serlet claimed that 90% of the projects within OS X were refined between 10.5 and 10.6. There are a sea of complexities under those three tentpoles. Exchange support was added to the Mac with 10.6, after being added to iOS previously.10.6 brought new under-the-hood technologies to the Mac that the platform relies on today.The release was full of refinements and little touches. ![]() Here are the three major points he made on stage: The fact that 10.6 was introduced by Bertrand Serlet says a lot. Under normal conditions, free-state Drp1 molecules are located in the cytoplasm. However, the relationship between morphological and functional changes in the mitochondria following hypoxia has not been fully elucidated.ĭynamin-related protein 1 (Drp1), as a mitochondrial fission-associated GTPase, is a classical protein affecting mitochondrial morphological changes. ![]() This mainly manifested as abnormal mitochondrial morphology (such as excessive fission, impaired fusion, etc.) and mitochondrial dysfunction (such as decreased ATP production, excessive ROS accumulation, etc.), which promoted organ dysfunction after hypoxia. In our previous study, we found significant mitochondrial damage in tissues and organs, such as vascular, intestines, and the heart, after hypoxic injury. The mitochondrion, as the main site of aerobic respiration in cells, is one of the organelles that undergo damage immediately after ischemia and hypoxia. Severe hypoxic injury can cause organ dysfunction and may be life-threatening. It is a common pathway for the initiation and development of various critical illnesses, such as hemorrhagic shock, sepsis, and cardiopulmonary failure. Hypoxic injury refers to tissue cell injury caused by insufficient blood perfusion and blood oxygen supply. Thus, our study interprets the dual direct regulation of mitochondrial Drp1 on mitochondrial morphology and functions after hypoxia and proposes a new mitochondrial fission-independent mechanism for the role of Drp1 after its translocation in hypoxic injury. Subsequently, the mPTP-related protein hexokinase 2 (HK2) is inactivated at Thr-473 and dissociates from the mitochondrial membrane, ultimately causing structural disruption and overopening of mPTP, which aggravates mitochondrial and cellular dysfunction after hypoxia. Then, leucine-rich repeat serine/threonine-protein kinase 2 (LRRK2) is recruited, whose kinase activity is inhibited by direct binding with mitochondrial Drp1 after hypoxia. Firstly, mitochondrial Drp1 maximumly recognizes mPTP channels by binding Bcl-2-associated X protein (BAX) and a phosphate carrier protein (PiC) in the mPTP. In this study, we performed a series of interaction and colocalization assays and found that, after mitochondrial translocation, Drp1 may promote the excessive opening of the mitochondrial permeability transition pore (mPTP) after hypoxia. However, in addition to mediating mitochondrial fission, whether Drp1 has other regulatory roles in mitochondrial homeostasis after mitochondrial translocation is unknown. The activation of dynamin-related protein 1 (Drp1), as well as its mitochondrial translocation, play important roles in the changes of both mitochondrial morphology and mitochondrial functions after hypoxia. ![]() Mitochondrial mass imbalance is one of the key causes of cardiovascular dysfunction after hypoxia. |
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